SATB2 has been implicated as causative in the cleft or high palate of individuals with 2q32q33 microdeletion syndrome. SATB2 was found to be disrupted in two unrelated cases with de novo apparently balanced chromosome translocations associated with cleft palate and Pierre Robin sequence.

SATB2 is a nuclear matrix attachment region-binding transcription factor with developmental role in craniofacial, neural, and osteoblastic differentiation. Several publications have documented SATB2 expression in the epithelium of the lower gastrointestinal tract (appendix, colon, and rectum).

SATB2 Is Expressed in Subcerebral and Corticothalamic Projection Neurons During Development. We determined whether SATB2 is expressed in corticofugal neurons by examining axons from SATB2-expressing neurons using the Satb2 lacZ allele, in which a beta-galactosidase gene (lacZ) was inserted in the Satb2 locus (16 ⇓ –18). Summaries for SATB2 gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio SATB2 Positive Control Slides, Product No. 384S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections). Physical form Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide. Preparation Note SATB2 (see below). Material The slide to be stained for SATB2 comprised: 1. Appendix, 2.

Satb2

Gene Ontology (GO) annotations related to this gene include sequence-specific DNA binding and chromatin binding . An important paralog of this gene is SATB1. The SATB2 gene encodes a nuclear matrix DNA-binding protein that specifically binds to genomic nuclear matrix attachment regions and participates in transcription regulation and chromatin remodeling (summary by Leoyklang et al., 2013 ). 2008-02-07 SAS (Glass Syndrome) SATB2 -associated Syndrome Is a rare, genetic disorder characterized by significant developmental delay with limited to absent speech, behavioral issues, and craniofacial anomalies.

SATB2 is a novel, sensitive marker for colorectal carcinoma. We hypothesized that SATB2 IHC can reliably identify primary and metastatic signet ring cell carcinomas of lower GI tract origin. SATB2 and CDX2 IHC was performed on 159 primary (n=93) and metastatic (n=66) signet ring cell carcinomas of GI tract origin and 13 metastatic breast carcinomas with signet ring cell features.

2019 American Journal of Medical Genetics John M. Opitz Young investigator Table 3. . Disorders to Consider in the Differential Diagnosis of SATB2-Associated Syndrome (SAS). 20.

SATB2-associated syndrome (SAS) is a multisystem disorder characterized by significant neurodevelopmental compromise with limited or absent speech, behavioral issues, and craniofacial anomalies. The following clinical findings, based on published reports of 76 individuals with a …

Expression of SATB2 (FLJ21474, KIAA1034) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. SATB2 is a nuclear matrix attachment region-binding transcription factor with developmental role in craniofacial, neural, and osteoblastic differentiation. Several publications have documented SATB2 expression in the epithelium of the lower gastrointestinal tract (appendix, colon, and rectum). The SATB2 gene provides instructions for making a protein that is involved in the development of the brain and structures in the head and face. The SATB2 protein directs development by controlling the activity of multiple genes in a coordinated fashion. 2021-04-13 SATB2 (SATB Homeobox 2) is a Protein Coding gene.

At an H‐score cutoff of ≥150, SATB2 was 69% sensitive/90% specific for Merkel cell carcinoma. 2012-02-21 · Knockout Tested Rabbit recombinant monoclonal SATB2 antibody [EPNCIR130A]. Validated in WB, IHC, Flow Cyt, ICC/IF and tested in Mouse, Rat, Human. Cited in 30 publication(s). and SATB2 expression in periampullary adenocarcinoma has not yet been described. Methods: Immunohistochemical expression of SATB1 and SATB2 was analysed in tissue microarrays with primary tumours and a subset of paired lymph node metastases from 175 patients operated with pancreaticoduodenectomy for periampullary adenocarcinoma. SATB2 is a novel, sensitive marker for colorectal carcinoma.
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It is a homologue of SATB1 protein. This gene is localized to human chromosome 2q33.1, and is highly conserved across different species. Immunogen SATB homeobox 2 recombinant protein epitope signature tag (PrEST) Application Expression of SATB2 (FLJ21474, KIAA1034) in cancer tissue.

SATB2-associated syndrome is a condition that affects several body systems.It is characterized by intellectual disability, severe speech problems, dental abnormalities, other abnormalities of the head and face (craniofacial anomalies), and behavioral problems.
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SATB2 role in odontogenic MSCs is poorly understood. The aim of this study was to investigate whether SATB2 can regulate self-renewal and osteo/odontogenic differ-entiation of odontogenic MSCs. Satb2 expression was detected in the rapidly renewing mouse incisor mesenchyme by immunofluorescence staining, quantitative RT-PCR and Western blot

We are excited to share these official information sheets about SATB2 -associated syndrome. Families can download the family version below as a resource to share with your clinical team, including your pediatrician and physician specialists, Speech-Language Pathologist, Occupational Therapist, Physical Therapist, Board 2021-02-25 The SATB2 Gene Foundation, Inc. was established to enrich the lives of individuals with SATB2- associated syndrome, including those diagnosed with the condition and their families, through support, research and education. Our mission will be met by raising awareness about the characteristics of SATB2- associated syndrome, providing support to 2021-02-02 SATB2-associated syndrome (SAS) is a multisystem disorder characterized by significant neurodevelopmental compromise with limited or absent speech, behavioral issues, and craniofacial anomalies. The following clinical findings, based on published reports of 76 individuals with a … Search for SATB2 syndrome (2q33.1) and Glass syndrome on Facebook, and message us!

27 Jan 2021 PDF | The SATB2-associated syndrome is a recently described syndrome characterized by developmental delay/intellectual disability with

Tested in Flow Cytometry, IF, IHC, ICC, WB applications. This antibody reacts with Human, Mouse, Rat. Supplied as 100ul in Liquid form antibody. 2020-09-15 SATB2 has been implicated as causative in the cleft or high palate of individuals with 2q32q33 microdeletion syndrome. SATB2 was found to be disrupted in two unrelated cases with de novo apparently balanced chromosome translocations associated with cleft palate and Pierre Robin sequence. 2017-01-24 · The SATB2-associated syndrome (SAS) is a recently described condition, characterized by developmental delay, intellectual disability with absent or limited language skills, palatal and dental abnormalities, behavioral problems, and unusual facial features. SATB2 -associated syndrome (SAS) is an autosomal dominant disorder. Almost all probands with SAS reported to date have the disorder as the result of a de novo genetic event.

Methods and results SATB2 Antibody (SATBA4B10) is available as the non-conjugated anti-SATB2 antibody.